2007 Lab Members

Andrew Merrell, Dr. Greta Binford, MG Weber, Liz Thompson, Justin Markham, Dr. Pamela Zobel-Thropp (left to right)

Research

The chemical richness and diversity of spider venoms make them interesting subjects for understanding how evolution generates novelty. My research program uses integrative, evolutionary approaches to better understand patterns of diversity in spider venoms. In my lab, students participate in evolutionary analyses of spider venoms at all levels of the process. This includes collecting a range of spiders in the field, doing protein analyses of the venoms, and using molecular approaches to study the genes that code for the venom proteins. We also are studying the evolutionary history of the spiders themselves to create a framework we can use to analyze venom evolution. Students also analyze the effects of venoms on insect prey and observe spider foraging behavior. These data help to better understand the role venom plays in immobilizing prey and how that varies across spider species.

Our current research is focused on brown recluse and their relatives (Loxosceles). We have discovered that the toxin in venoms of Loxosceles that causes dermonecrotic lesions (sphingomyelinase D) is also present in venoms of some species in the closely related genus Sicarius. This means this toxin likely originated in an ancestor of these two types of spiders. This knowledge helps us better understand the range of species related to the brown recluse that is capable of causing lesions when these animals bite people. Knowing how the toxin varies among species may help to facilitate development of treatments that will work for bites of all members of this group of spiders.