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Discussion of Zennou et al:
"HIV-1 Genome Nuclear Import is Mediated by a Central DNA Flap"

Announcements:

• We DO have lab this Wednesday--we'll be exchanging and critiquing drafts of the final paper
  • Your draft is due at 12:40 pm, and is worth 5 points
  • You need to bring 3 copies of your draft, 1 for each peer reviewer
  • Your peer review (completed in lab) is worth 5 points
  • Plan on staying for a few hours, until 4 pm or so
• Wednesday's class (311) is an exam review session--bring your questions!
• I am willing to do a second review session on Friday--let me know if you're interested, and what times would work for you
• Homework #12 is graded, and the key is online

Learning objectives for Mon 12/11/00

Students should be able to…

1. Explain any of the experiments presented in figures 1-4 of Zennou et al. Your explanation should include the rationale behind each experiment (why it was done), the basic outlines of the technique (how it was done), and a careful analysis of the data (what the data show).

Complete figures from Zennou et al, for class discussion

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

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