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DNA Damage and
Repair
Monday, Nov 20, 2000
Dr. Suzanne Deschenes
Announcements:
- Exam II is now graded, and the key is online
- Don't forget--the next outside reading discussion is Mon
11/27, right after Thanksgiving break. The reading is on reserve
(it's at the reserve desk, and should be posted online shortly),
and the homework will be posted today. Good scans of the figures
are available at our website.
- We DO have class on Wednesday. I'll be discussing
recombination and recombinational repair, both of which will be
covered on the (comprehensive) final exam. We DON'T have lab,
however.
Learning objectives for Mon 11/20/00
Students should be able to…
- Describe the main types of DNA damage and their sources.
- Identify what repair pathway would be used to correct each
type of damage, and describe the basic mechanisms.
- Describe the themes common to all forms of DNA repair.
Outline:
- Types of DNA damage and their most common sources
- Themes common to all forms of DNA repair.
- Proof-reading by polymerases as a first line of defense for
replication errors.
- Mismatch repair is the second line of defense for replication
errors.
- Excision repair - base vs nucleotide, when and how.
- The consequences of defects in DNA repair: Human
diseases.
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Created by:
bkbaxter@lclark.edu
Updated: 20 Nov 00