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Cell Biology BIO361 Fall 2008 |
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Lewis and Clark Department of Biology |
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| Class: T, Th; 9:40 AM-11:10 AM in Howard 101 Lab: Th 1-4 PM in Blue Lab Office Hours: T 2-3 PM, W 11:30-12:30 PM, by appointment, and when my door is open |
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| Instructor: Greg Hermann Office: Bio-Psych 226 Phone: x7568 Email: hermann@lclark.edu |
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| Above are images of a ppk-3(-) Caenorhabditis elegans adult visualized using fluorescence microscopy. ppk-3(-) intestinal cells contain enlarged late endosomal/lysosomal compartments (Nicot ey al. 2005 Mol. Biol. Cell 17:3062-3074). LMP-1::GFP is green rings, RAB-7::RFP is red rings, and gut granules are the solid green balls. PPK-3 is homologous to PIKfyve, a protein implicated in controlling lysosomal morphology in humans. Students in BIO361 perform original research investigating the role of the PPK-3 in C. elegans lysosome formation. | |||||||||||||
| Welcome to the field of biology that aims to understand the structure and function of the fundamantal unit of life - the cell. In this course our study of cells will consider five major unanswered questions in the field: (1) How are organelles made? (2) How do cells move? (3) How do organisms control their cell number? (4) How do cells communicate? (5) What mechanisms cause cancer? In considering our current answers to these questions we will integrate microscopic, biochemical, genetic, molecular, and systems approaches to the study of cells. We will discuss some of the hypotheses, experiments, and results that have led to our current (and only partially complete) answers to these questions. We will read and discuss primary literature articles that investigate how pathogens co-opt these normal cellular processes. Our own studies of cell biology will focus on understanding how an organelle, the lysosome, is constructed in the model organism C. elegans. | |||||||||||||
| Course Syllabus | Course Schedule | Lab Syllabus and Schedule | 2007 (Old) Course Schedule | ||||||||||